Responding to the request of the Dominican Friars to work with them in beginning a mission in Pakistan, 8 Sisters set out on a journey to a new climate, culture, language, and attire. Led by Sr. Purissima Reilly, they arrive in Karachi on October 12, 1958. By 1965, they will have built schools in various parts of the country, educating thousands of Muslim and Christian children. Families are receiving pastoral visits, encouragement, and practical assistance. Dispensaries are opened where wounds are healed and medicine distributed. In 2021, with one U.S. Sister remaining, 21 Pakistani Dominican Sisters of Sparkill are serving the Pakistani people with competence and compassion.